High school iGEM group

trevor.kenney — Wed, 11 Jul 2012 21:22:21 +0000

A group of Lethbridge and area high school students who want to take NASA technology and use it to help reduce the affects of Type 1 Diabetes recently came away from an international competition with an award for their research presentation -- and will be further recognized by the ��Ѹ��Դ��߿�Ƭ of Lethbridge with $36,000 worth of scholarships ($1,000 per student).

Six students, members of the ��Ѹ��Դ��߿�Ƭ of Lethbridge 36-person High School iGEM (International Genetically-engineered Machines) team made their first trip to the Indianapolis, IN contest as the only Canadian contingent, and presented their take on how to use an innovative, implantable capsule (developed by NASA to release medication in space) to manage the release of insulin for people with Type 1 Diabetes.

The U of L High School iGEM Team. Back row (from L to R) Yoyo Yao, Erin Kwan, Janelle Veenendaal, Chris Isaac, Dax Law, Devan Carrier, Brianna Carrels, Trisha Bouma. Middle Row (from L to R) Orion Sehn, Branden Black, Marissa Guzzi, Cassandra Logue, Shammamah Hossain, Maya Many Grey Horses, Elaine Bird. Front Row (from L to R) Dawson Meyer, Erin Kelly, Brooke Heatherington, Alycia Amatto, Wesley Mosimann, Katelyn Harder. Missing in photo are Natalia Mitura, Iain Sander, Gerardo Karari Balderas Figueroa, Carissa Kirk, Corbin Chenger, Alli Herauf, Riley Martens, Jared Sparkes, Teddi Reynolds and Marie Cooney.

The group plans to engineer a bacteria that will secrete insulin in response to a person's glucose levels, then house it in the NASA biocapsule (so it is contained and not flowing freely in the bloodstream) where it will safely dispense insulin and could reduce the need for the continuous monitoring, injections and other challenges currently experienced by the hundreds of millions of people worldwide with diabetes.

Bold? Absolutely. Can it be done? That's what the group intends to find out.

That's why the U of L is rewarding them with scholarships – to help them pursue their interest in science and research at the U of L.

The $1,000 scholarship credit per student covers the cost of about two courses, and is available upon their successful application and acceptance to the ��Ѹ��Դ��߿�Ƭ. The students will be presented with their awards at a brief ceremony that takes place Wednesday, July 11 beginning at 4 p.m. in Anderson Hall, room AH100 (Andy's Place).

"When the iGEM competition expanded to include high school students, the U of L saw an opportunity to follow suit and this year 36 students participated in the program," says Dr. Andy Hakin, the U of L's provost and vice president (academic). "Not only does this provide valuable hands-on learning opportunities, but it also augments the existing Alberta science curriculum. We are happy to be able to extend this world-class program into local high schools, exposing younger students to the unique opportunities available by pursuing a science education."

Team spokesperson Erin Kelly, a recent Catholic Central High School graduate entering fist year at the U of L in the fall, says the group brainstormed ideas with U of L iGEM team members and chemistry and biochemistry researchers that had a combination of what she describes as 'do-ability' and social relevance. They also looked to past iGEM projects for inspiration, since the work created by all iGEM teams worldwide is in the public domain and archived in the interests of conducting innovative research.

"A team at Berkeley created bacteria that could produce haemoglobin (a key component of blood) to function as a new type of red blood cell," says Kelly. "We would like to try this with the cells in the pancreas, which were damaged by the onset of Type 1 Diabetes. Another team from Missouri had figured out how to get the cell to detect glucose, which would let the cell know when there is too much sugar. Once glucose is detected, we could work on secreting insulin."

Kelly says the NASA capsule is a perfect place to house the bacteria, sustain it, and act as a filter to move the insulin from the capsule to the person.

"We would have a lot of work to do before we can get to that stage, because we have to engineer some other steps into the process. We expect that a project like this would be one that could carry through a few years of iGEM teamwork, and could be used by other teams to move their own projects forward."

At the U of L, the iGEM team concept has evolved to a point where the university-level group runs its own funded lab, regularly places in the top levels of international competitions, and has provided a significant boost to undergraduate students who wish to pursue further research at a masters level.

Their ongoing project involves engineering bacteria to recognize – and consume – harmful materials in oilsands tailings ponds.

"We have welcomed high-school researchers to the U of L iGEM group in the past, but to have this large number of interested and engaged students is a really great experience for all of us," says Dr. Hans-Joachim Wieden, a U of L biochemistry researcher and one of the faculty supervisors for both groups. "The additional support the students are receiving from the ��Ѹ��Դ��߿�Ƭ in the form of scholarships is a great indicator of their achievement, and we look forward to having them join us as students when they begin their university studies. "

STUDENT NAMES, GRADES AND HIGH SCHOOL AFFILIATION

Lethbridge Collegiate Institute

Dax Law 11
Erin Kwan 12
Cassandra Logue 11
Devan Carrier 11
Teddi Reynolds 12
Gerardo Karari Balderas Figueroa 11

Catholic Central High School

Erin Kelly 12
Elaine Bird 11
Corbin Chenger 12
Carissa Kirk 10
Brooke Heatherington 11
Riley Martens 12
Marissa Guzzi 12
Branden Black 11
Katelyn Harder 11
Natalia Mitura 12
Iain Sander 11
Marie Cooney 11
Alycia Amatto 11

Chinook High School

Brianna Carrels 10
Yoyo Yao 11
Chris Isaac 11
Jared Sparkes 11
Maya Many Grey Horses 11
Wesley Mosimann 11
Dawson Meyer 11
Alli Herauf 10

Winston Churchill High School

Shammamah Hossain 11
Orion Sehn 10

Immanuel Christian High School

Janelle Veenendaal 11
Trisha Bouma 11

Cleaning up the oil sands

trevor.kenney — Fri, 16 Jul 2010 15:36:00 +0000

A group of ��Ѹ��Դ��߿�Ƭ of Lethbridge undergraduate chemistry, biochemistry and neuroscience students is taking on the challenge of trying to help clean up toxins in oil sands tailings ponds.

The 11-member group has been awarded a $20,000 international research grant to help solve a challenge posed by a consortium of leading energy companies – find a biological solution to improve the environmental sustainability of Alberta's oil sands bitumen extraction, upgrading and refining.

"As a team from Alberta, we know of the economic benefit that the oil sands have brought to the province," says team spokesperson Justin Vigar. "Many members on our team have friends and family employed around the province in the energy industry.
"However, we are also aware of the environmental impact of the oil sands, specifically the tailings ponds. We feel it is important not only to clean the tailings ponds, but be able to extract the potential energy of the residue bitumen at the same time."

The students are members of the multiple-award-winning International Genetically Engineered Machines (iGEM) team at the U of L. Each year, the iGEM team takes on a synthetic biology research project, which is then presented at an international competition held at the Massachusetts Institute of Technology (MIT) in Boston, Mass.

The group was the only team in the iGEM worldwide membership to receive $20,000 from the Oil Sands Initiative to study how petrochemical-eating bacteria could be used to help clean up water in tailings ponds. The ponds are a byproduct of the bitumen refining process in which water that cannot be recycled is deposited into large ponds to settle.

Vigar adds that the iGEM team has previously worked on related projects, giving them a significant advantage when facing this new challenge.

"Our iGEM teams have designed a variety of synthetic biology components that all relate to this new project," he says. "One year, the team created a biological 'switch' that directed bacteria to move toward certain types of contaminants. The next year, we refined that to make the bacteria consume a specific chemical compound, and then stop reproducing – we called it a 'bacuum cleaner.' Last year, we designed what we called 'bio-batteries' that use bacteria with photosynthetic properties to generate electrical currents."

Vigar says the group hopes to accomplish several things with its research.

"We intend to create and characterize biological parts that can be used in the efforts of cleaning the tailings ponds, and those parts will be available to the general public for use in the future through the Registry of Standard Biological Parts, housed at MIT."

The other benefit will be to the team members as they progress in their academic and post-university careers.

"This experience will be extremely beneficial to enhance team members independent and critical thinking," says Vigar.
"As well, we learn how classroom knowledge can be directly applied in helping to solve everyday issues – specifically the application of synthetic biology to engineer solutions. iGEM has spurred our scientific creativity in what we can and cannot do, and has opened our eyes to not only the field of synthetic biology, but made us more aware of the research community in general."

UNews - Team spokesperson

High school iGEM group

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Cleaning up the oil sands

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