UNews - Elaine Bird

Excelling on the world stage

david.kirby — Fri, 22 Nov 2013 15:14:55 +0000

Learning from the best – that’s exactly what a group of research-focused students is doing at the ��Ѹ��Դ��߿�Ƭ of Lethbridge.

Members of the U of L’s International Genetically Engineered Machine (iGEM) team are part of a phenomenon that began 10 years ago as a course at the Massachusetts Institute of Technology (MIT). Today, the annual iGEM contest is the world’s leading undergraduate synthetic biology competition – and each year, U of L students regularly rank among the top iGEM teams worldwide.

An emerging field, synthetic biology sees cells, enzymes and metabolic pathways as more than biological entities; they’re sophisticated parts that can be programmed like machines to perform specific activities. As a result, research in synthetic biology is opening up remarkable possibilities in such sectors as agriculture, pharmaceutical, medical diagnostics, clean energy and resource extraction. In 2011, for example, U of L students developed a petrochemical-eating bacteria that could be used to help clean up water in tailings ponds, a discovery that placed the ��Ѹ��Դ��߿�Ƭ’s iGEM team among the top 16 competitors in the world, alongside students from Harvard ��Ѹ��Դ��߿�Ƭ, MIT, the ��Ѹ��Դ��߿�Ƭ of Washington and Johns Hopkins ��Ѹ��Դ��߿�Ƭ.

This October, the U of L’s iGEM team once again demonstrated its strong innovation abilities. In addition to creating a bioengineering part that works like a zip drive, compressing genetic information, the team developed software that rapidly determines what DNA sequences are compatible to compress together. These inventions, which will allow future bioengineers more flexibility in their research, captured top prize in the 2013 North American iGEM Regional Jamboree held in Toronto. Moreover, the first-place finish secured the team – made up of Dustin Smith (BSc ’13), Graeme Glaister, Jenna Friedt (BSc ’11, MSc ’13), Suneet Kharey, Harland Brandon (BSc ’13) and Zak Stinson – a spot in the international iGEM competition at MIT in November, where the team claimed two prominent awards.

iGEM students are representing the U of L on the world stage. Back row (L-R) Harland Brandon (BSc ’13), Dustin Smith (BSc ’13), Graeme Glaister, Zak Stinson and Dr. H.J. Wieden (faculty advisor). Front row (L-R) Suneet Kharey and Jenna Friedt (BSc ’11, MSc ’13). (Photo by Leslie Ohene-Adjei)

Providing students with the opportunity to compete against teams from around the world is just one way iGEM benefits its participants, says U of L biochemistry professor Dr. Hans-Joachim (H.J.) Wieden. Considered the driving force behind the U of L’s iGEM teams, Wieden serves as the students’ advisor and coach. He is also a highly respected researcher in his own right.

Director of the Alberta RNA (ribonucleic acid) Research and Training Institute at the U of L, Wieden was also recently appointed the Innovates Centre of Research Excellence (iCORE) Chair of Bioengineering. Funded by a $2-million investment from Alberta Innovates-Technology Futures, the role enables Wieden’s research team to study how biological systems can be engineered to achieve breakthroughs in materials science, chemistry, biochemistry, health and nanoscience.

“iGEM enables students to get their first taste of research,” says Wieden. “They understand the goal of the project, and learn how to think outside of the box, troubleshoot and apply their knowledge to create scientific discoveries. All of this unlocks students’ creativity.”

What’s more, he continues, iGEM cultivates students’ entrepreneurial potential. The teams manage their own projects and raise funds to support their work, as well as learn how to communicate effectively and connect their work to real-world needs. Finally, as young researchers themselves, they come to realize the importance of supporting the forward-thinking scientists of the future: high school students.

To that end, U of L students have started iGEM teams in high schools in southern Alberta. And those high school students are following in the success of their older counterparts. Earlier this year, in fact, a team of Lethbridge high school students representing schools from across the city, won the Green Brick grand prize at iGEM’s international High School Jamboree at MIT, as well as trophies for Best New Biobrick Natural for their engineered DNA part and Best Wiki, the website used to display their project.

Advised by Wieden as well as U of L undergraduate and graduate students, the high school team – consisting of 22 students from Lethbridge-area high schools, including Kieran McCormack, Chris Isaac, Elaine Bird, Fiona Spitzig, Yoyo Yao, Patrick O’Donnell and Katie Thomas, who represented the team at the jamboree – successfully created a longer lasting form of Oxytocin. A hormone that’s most-commonly used to aid childbirth, Oxytocin degrades quickly and soon becomes unstable, making it expensive and difficult to store.

While such complex projects can be challenging for high school students, the research experience is invaluable, says former iGEM high school team member Erin Kelly.

“Being on the high school team was a steep learning curve, but I learned research methods through hands-on experience and that definitely made the transition to university easier,” says Kelly. Now a second-year biochemistry student at the U of L, she serves as an advisor to the current iGEM high school team along with fourth-year neuroscience student Isaac Ward and master of biochemistry student Mackenzie Coatham (BSc ’12).

U of L iGEM students Isaac Ward, Mackenzie Coatham (BSc ’12), Harland Brandon (BSc ’13) and Erin Kelly are using their research and entrepreneurial skills to launch their own company. (Photo by Leslie Ohene-Adjei)

The trio, all former members of the undergraduate iGEM team, have used their resulting research and entrepreneurial skills to launch the spinoff company Synbiologica Ltd. Along with Brandon (now a U of L master’s student in biochemistry), and U of L neuroscience professor Dr. Gerlinde Metz and Wieden as advisors, the group is in the process of patenting their big idea – a biomedical technology that provides rapid hormone-detection results. Their idea is expected to be 93 per cent more cost-effective than traditional antibody technology, bringing the next generation of hormone detection to the research, agriculture and medical markets.

In recognition of its scientific innovation, the Synbiologica team has earned numerous accolades. They include winning $10,000 in the South Venture Business Plan Competition and taking first place in the Tech Stream side of the Chinook Entrepreneurial Challenge, an annual business-planning competition hosted by Community Futures Lethbridge Region. The group received an additional $10,000 in cash, a one-year lease on space in the tecconnect: An Alberta centre for new commerce – a high-tech business incubator operated by Economic Development Lethbridge – plus a range of other in-kind prizes, including business consulting from MNP and ActionCOACH, and several thousand dollars worth of media services.

“iGEM gave us the motivation and skills to explore multidisciplinary research,” says Ward, chief executive officer of Synbiologica. “And from there, we realized that we don’t have to follow the usual career route. We can create our own jobs.”

Excelling on the world stage

trevor.kenney — Tue, 22 Oct 2013 22:03:53 +0000

Learning from the best – that’s exactly what a group of research-focused students is doing at the ��Ѹ��Դ��߿�Ƭ of Lethbridge.

��Ѹ��Դ��߿�Ƭ of Lethbridge iGEM students Isaac Ward, Mackenzie Coatham, Harland Brandon and Erin Kelly are among the best young researchers in the world.

This October, the U of L’s iGEM team once again demonstrated its strong innovation abilities. In addition to creating a bioengineering part that works like a zip drive, compressing genetic information, the team developed software that rapidly determines what DNA sequences are compatible to compress together. These inventions, which will allow future bioengineers more flexibility in their research, captured top prize in the 2013 North American iGEM Regional Jamboree held in Toronto. Moreover, the first-place finish secured the team – made up of Dustin Smith (BSc ’13), Graeme Glaister, Jenna Friedt (BSc ’11, MSc’13), Suneet Kharey, Harland Brandon (BSc ’12) and Zak Stinson – a spot in the international iGEM competition, which will be held at MIT in November.

Director of the Alberta RNA (Ribonucleic acid) Research and Training Institute at the U of L, Wieden was also recently appointed the Innovates Centre of Research Excellence (iCORE) Chair of Bioengineering. Funded by a $2-million investment from Alberta Innovates-Technology Futures, the role enables Wieden’s research team to study how biological systems can be engineered to achieve breakthroughs in materials science, chemistry, biochemistry, health and nanoscience.

Advised by Wieden as well as U of L undergraduate and graduate students, the high school team – consisting of 22 students from Lethbridge-area high schools, including Keiran McCormack, Chris Isaac, Elaine Bird, Fiona Spitzig, Yoyo Yao, Patrick O'Donnell and Katie Thomas, who represented the team at the jamboree – successfully created a longer lasting form of Oxytocin. A hormone that’s most-commonly used to aid childbirth, Oxytocin degrades quickly and soon becomes unstable, making it expensive and difficult to store.

While such complex projects can be challenging for high school students, the research experience is invaluable, says former iGEM high school team member Erin Kelly.

The trio, all former members of the undergraduate iGEM team, have used their resulting research and entrepreneurial skills to launch the spinoff company Synbiologica Ltd. Along with Brandon (now a
U of L master’s student in biochemistry), and U of L neuroscience professor Dr. Gerlinde Metz and Wieden as advisors, the group is in the process of patenting their big idea – a biomedical technology that provides rapid hormone-detection results. Their idea is expected to be 93 per cent more cost-effective than traditional antibody technology, bringing the next generation of hormone detection to the research, agriculture and medical markets.

High school iGEM group

trevor.kenney — Wed, 11 Jul 2012 21:22:21 +0000

A group of Lethbridge and area high school students who want to take NASA technology and use it to help reduce the affects of Type 1 Diabetes recently came away from an international competition with an award for their research presentation -- and will be further recognized by the ��Ѹ��Դ��߿�Ƭ of Lethbridge with $36,000 worth of scholarships ($1,000 per student).

Six students, members of the ��Ѹ��Դ��߿�Ƭ of Lethbridge 36-person High School iGEM (International Genetically-engineered Machines) team made their first trip to the Indianapolis, IN contest as the only Canadian contingent, and presented their take on how to use an innovative, implantable capsule (developed by NASA to release medication in space) to manage the release of insulin for people with Type 1 Diabetes.

The U of L High School iGEM Team. Back row (from L to R) Yoyo Yao, Erin Kwan, Janelle Veenendaal, Chris Isaac, Dax Law, Devan Carrier, Brianna Carrels, Trisha Bouma. Middle Row (from L to R) Orion Sehn, Branden Black, Marissa Guzzi, Cassandra Logue, Shammamah Hossain, Maya Many Grey Horses, Elaine Bird. Front Row (from L to R) Dawson Meyer, Erin Kelly, Brooke Heatherington, Alycia Amatto, Wesley Mosimann, Katelyn Harder. Missing in photo are Natalia Mitura, Iain Sander, Gerardo Karari Balderas Figueroa, Carissa Kirk, Corbin Chenger, Alli Herauf, Riley Martens, Jared Sparkes, Teddi Reynolds and Marie Cooney.

The group plans to engineer a bacteria that will secrete insulin in response to a person's glucose levels, then house it in the NASA biocapsule (so it is contained and not flowing freely in the bloodstream) where it will safely dispense insulin and could reduce the need for the continuous monitoring, injections and other challenges currently experienced by the hundreds of millions of people worldwide with diabetes.

Bold? Absolutely. Can it be done? That's what the group intends to find out.

That's why the U of L is rewarding them with scholarships – to help them pursue their interest in science and research at the U of L.

The $1,000 scholarship credit per student covers the cost of about two courses, and is available upon their successful application and acceptance to the ��Ѹ��Դ��߿�Ƭ. The students will be presented with their awards at a brief ceremony that takes place Wednesday, July 11 beginning at 4 p.m. in Anderson Hall, room AH100 (Andy's Place).

"When the iGEM competition expanded to include high school students, the U of L saw an opportunity to follow suit and this year 36 students participated in the program," says Dr. Andy Hakin, the U of L's provost and vice president (academic). "Not only does this provide valuable hands-on learning opportunities, but it also augments the existing Alberta science curriculum. We are happy to be able to extend this world-class program into local high schools, exposing younger students to the unique opportunities available by pursuing a science education."

Team spokesperson Erin Kelly, a recent Catholic Central High School graduate entering fist year at the U of L in the fall, says the group brainstormed ideas with U of L iGEM team members and chemistry and biochemistry researchers that had a combination of what she describes as 'do-ability' and social relevance. They also looked to past iGEM projects for inspiration, since the work created by all iGEM teams worldwide is in the public domain and archived in the interests of conducting innovative research.

"A team at Berkeley created bacteria that could produce haemoglobin (a key component of blood) to function as a new type of red blood cell," says Kelly. "We would like to try this with the cells in the pancreas, which were damaged by the onset of Type 1 Diabetes. Another team from Missouri had figured out how to get the cell to detect glucose, which would let the cell know when there is too much sugar. Once glucose is detected, we could work on secreting insulin."

Kelly says the NASA capsule is a perfect place to house the bacteria, sustain it, and act as a filter to move the insulin from the capsule to the person.

"We would have a lot of work to do before we can get to that stage, because we have to engineer some other steps into the process. We expect that a project like this would be one that could carry through a few years of iGEM teamwork, and could be used by other teams to move their own projects forward."

At the U of L, the iGEM team concept has evolved to a point where the university-level group runs its own funded lab, regularly places in the top levels of international competitions, and has provided a significant boost to undergraduate students who wish to pursue further research at a masters level.

Their ongoing project involves engineering bacteria to recognize – and consume – harmful materials in oilsands tailings ponds.

"We have welcomed high-school researchers to the U of L iGEM group in the past, but to have this large number of interested and engaged students is a really great experience for all of us," says Dr. Hans-Joachim Wieden, a U of L biochemistry researcher and one of the faculty supervisors for both groups. "The additional support the students are receiving from the ��Ѹ��Դ��߿�Ƭ in the form of scholarships is a great indicator of their achievement, and we look forward to having them join us as students when they begin their university studies. "

STUDENT NAMES, GRADES AND HIGH SCHOOL AFFILIATION

Lethbridge Collegiate Institute

Dax Law 11
Erin Kwan 12
Cassandra Logue 11
Devan Carrier 11
Teddi Reynolds 12
Gerardo Karari Balderas Figueroa 11

Catholic Central High School

Erin Kelly 12
Elaine Bird 11
Corbin Chenger 12
Carissa Kirk 10
Brooke Heatherington 11
Riley Martens 12
Marissa Guzzi 12
Branden Black 11
Katelyn Harder 11
Natalia Mitura 12
Iain Sander 11
Marie Cooney 11
Alycia Amatto 11

Chinook High School

Brianna Carrels 10
Yoyo Yao 11
Chris Isaac 11
Jared Sparkes 11
Maya Many Grey Horses 11
Wesley Mosimann 11
Dawson Meyer 11
Alli Herauf 10

Winston Churchill High School

Shammamah Hossain 11
Orion Sehn 10

Immanuel Christian High School

Janelle Veenendaal 11
Trisha Bouma 11

UNews - Elaine Bird

Excelling on the world stage

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Excelling on the world stage

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High school iGEM group

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