UNews - MRI

CCBN renovation creates enhanced research area

trevor.kenney — Thu, 27 Sep 2012 22:42:32 +0000

The Canadian Centre for Behavioural Neuroscience (CCBN) has undergone some major renovations in the past few months to improve the space where world-renowned research is being conducted.

The former in situ lab at the CCBN was quickly outgrowing the needs of the expanding Polaris Brain Dynamics Research Group at the ��Ѹ��Դ��߿�Ƭ of Lethbridge. But thanks to funding from the Canada Foundation for Innovation, a new, larger lab and animal facility – an addition of 224-square metres – has been built to better suit researchers' needs.

The new lab is a modern space with the capacity to operate multiple workstations simultaneously. Previously, researchers would have to travel from room to room to gather supplies or use a particular piece of equipment, while changing lab coats and other protective gear between rooms.

Research technician Aubrey Demchuk prepares an experiment in the CCBN's new in situ lab that offers much more space than the previous lab.

Research technicians Valérie Lapointe and Aubrey Demchuk, who help to manage the lab and assist undergraduate and graduate students, post-doctoral fellows and principal investigators with their research, say the extra space has greatly improved their working conditions.

"The room where we were doing the experiments before was very tiny. We could only work with a few people at a time, and we'd kind of walk on one another," says Lapointe, who was part of the planning and design process for the new in situ lab. "It's nice that it is bigger and that everything is here in one room."

"We're really lucky to have as much space as we have now," says Demchuk.

Dr. Bruce McNaughton, Alberta Heritage Foundation for Medical Research (AHFMR) Polaris Research Chair, says many projects were put on hold until the new lab could be built.

"We now have an outstanding neural imaging facility for both live animal imaging and quantitative microscopy. As well as an integrated center for neuroscience data analysis, with workstations connected to our parallel supercomputing facility," he says. "These new facilities will enable a big increase in lab productivity and the output of high quality basic and preclinical neuroscience."

When it came to building the lab, most of the work was in the details, says project manager Brad Robinson.

"You can see, the counters are just full of lab equipment, so I had to do elevation views of each wall and know where each piece of equipment was going, where the plug was going, where the data plug was going, where the light switches were going, where the thermostats were going and so on. I had to know where everything needed to be logistically to create a well-organized, functioning lab," he says.

The rodent research facility at CCBN also received an overhaul. It now features 45 animal experiment/research rooms, six surgery suites, a quarantine room, seven animal housing rooms, an MRI room, an MPE (multiphoton electron) microscope room and an optical imaging room equipped with specialized LED surgical lights and Nederman gas extractor arms that can be placed almost anywhere near a surgery table to exhaust vapours.

Making renovations to the CCBN's animal facility wasn't without its challenges. Construction work can severely impact research. Simply drilling a hole into the drywall contaminates a room. The preparation and planning to shut down an area of the facility can take longer than the actual construction work, but if the proper precautions are not taken, the entire animal facility could be contaminated and thousands of hours of research work would be lost.

"Shutting down parts of the building to tie the new infrastructure into the existing infrastructure was a real team effort," says Robinson.

This story first appeared in the September 2012 issue of the Legend. For a look at the full issue in a flipbook format, follow this link.

On the forefront of an emerging science

trevor.kenney — Tue, 20 Dec 2011 22:05:42 +0000

Humans have long wished to see beyond what our limited vision permits. For proof, consider the invention of microscopes, telescopes and satellites. Today at the ��Ѹ��Դ��߿�Ƭ of Lethbridge, researchers are using state-of-the-art digital imaging technologies to view even more areas – within the body and across the planet – that would otherwise be inaccessible to mortal eyes. Along the way, vast amounts of data are being collected.

"Solutions to the world's biggest problems can be resolved with high-quality, reliable data," says Dr. Daniel Weeks, the U of L's vice-president (research). "Our researchers are gathering, analyzing and making data more useful so important decisions can be made faster and more easily."

The emerging science of digital imaging is being pushed by researchers across disciplines at the ��Ѹ��Դ��߿�Ƭ of Lethbridge.

For example, using sensors to acquire information about the Earth's surface (a process called remote sensing) can help farmers evaluate the health of their crops. In medicine, similarly, magnetic resonance imaging, which produces 3-D images of soft tissue, can enable doctors to assess a patient's brain after a stroke.

For these reasons, and many more, imaging was named one of the top 20 greatest engineering achievements of the 20th century by the National Academy of Engineering in the United States. Indeed, imaging is effecting enormous change in multiple fields. In recent years, the U of L has attracted numerous international imaging-science researchers in such diverse disciplines as physics, astronomy, kinesiology, geography, neuroscience and new media. As a result, the ��Ѹ��Դ��߿�Ƭ identified imaging as a key area for growth.

There are many on-campus facilities dedicated to supporting imaging research at the U of L. They include two remote-sensing laboratories, a brain-imaging centre and a soon-to-be completed and unique-in-Canada facility for calibrating remote-sensing instruments. Also, the ��Ѹ��Դ��߿�Ƭ is home to a satellite-receiving station that is operated in conjunction with Iunctus Geomatics Corp., founded by U of L alumnus Ryan Johnson (BSc '98, MSc '00).

Two researchers benefiting from those facilities are Dr. Craig Coburn of the Department of Geography and Dr. Albert Cross of the Departments of Neuroscience, and Physics and Astronomy.

Coburn is finding new ways to solve problems with, and extract information from, remotely sensed data. He has built remote-sensing instruments for such clients as the U.S. Naval Research Laboratory and the U.S. Army Corps of Engineers. And while the official use of the instruments is classified, Coburn speculates their job may be to spot disturbances in soil. This data could indicate the presence of landmines, for example.

"Imaging is about more than pictures," says Coburn, reflecting broadly on the field. "These are scientific-grade research instruments floating in space and they can provide a lot of valuable information if we know how to render the image."

The same is true of neuroimaging instruments, says Cross. "Using functional magnetic resonance imaging (MRI), we can track activity in the brain and unravel how the brain is organized."

An MRI physicist, Cross is developing new, minimally invasive techniques for neuroimaging. Using lab rats, Cross is studying the efficacy of manganese as a way to produce contrast changes in regions of the brain that correspond to prior experiences during MRI scans.

Imaging science can effect tremendous change in many fields, Weeks believes. On that note, the ��Ѹ��Դ��߿�Ƭ plans to broaden the impact of its imaging science research. "We're reaching out to potential partners in China, India and Germany, for instance. By finding new collaborators and exploring new avenues of discovery together, we can further increase the ��Ѹ��Դ��߿�Ƭ's global footprint in this exciting area of investigation."

Extraterrestrial

Long before Star Trek popularized the phrase, "To boldly go where no man has gone before," humanity has been interested in the cosmos. But sending people deep into space is dangerous and expensive. Fortunately, extraterrestrial imaging enables us to find faraway stars, galaxies and planets, and puts the universe in closer reach.

Neuroimaging

We already have proof that the brain is a powerful tool. You do, after all, remember the location of your keys (most days). But in what areas of the brain does thinking actually happen? And how does the whole system work? By providing images of the brain as it goes about its business, neuroimaging offers important insights about the process of cognition.

Motion capture

Movement is something many of us take for granted. But researchers know there's more to human motion than heaving yourself out of bed, running around with a to-do list and then crashing on the couch. What are the subtle mechanics of motion? Knowing this information will advance our understanding of how bodies move, and will benefit everything from the fine arts to the field of kinesiology.

Atmospheric

The air that surrounds our planet may appear clear some days and a smoggy soup on others. But no matter the atmosphere's appearance, there's always a mix of gases up there. Some have little impact on our weather. Others, like carbon dioxide, are dramatically changing our climate. Atmospheric imaging researchers study the composition of the Earth's atmosphere and detect the trace gases that can be climatic game-changers.

Satellite

We've come a long way from the days of setting out on long expeditions to record the contours and features of the land. Today, we look above to satellites for a big-picture view of the planet. But small details are significant, too. For instance, what's happening on the Earth's surface in each region of the world? Satellite imaging enables us to see such phenomena as deforestation and the development of deserts.

Fenske made the most of his U of L opportunities

trevor.kenney — Mon, 24 Jan 2011 21:50:46 +0000

When he enrolled in psychology at the ��Ѹ��Դ��߿�Ƭ of Lethbridge, Dr. Mark Fenske (BSc '96, Distinction) had a goal – he wanted to help people.

The associate professor in the Department of Psychology at the ��Ѹ��Դ��߿�Ƭ of Guelph, and co-author of the Canadian best-seller, The Winner's Brain: 8 Strategies Great Minds Use to Achieve Success, initially thought about becoming a counsellor. But after the opportunity to work as a research assistant for
Dr. Scott Allen opened up, Fenske found he was hooked on cognitive psychology.

"Lethbridge has some really good people. You get to know these people on a level that you probably wouldn't at a larger institution," says Fenske. "Working with Drs. Scott Allen, John Vokey and Don Read, who were the cognition faculty in the psychology department at the time, was a bit of an awakening for me. I was able to learn about memory, about how we interact with the world around us, what drives our behaviour, how we make decisions and how we pay attention.
"I learned there is so much more to psychology than the commonly-held view of people lying on a couch and talking about their problems."

Alumnus Mark Fenske is thankful for the research foundation he established while still an undergraduate student.

Fenske made the most of his one-on-one opportunities with faculty.

"I was able to get a lot of face time with faculty and learn what life in a research lab is all about," he says. "It really cultivated a sense of excitement for research, and I was given a lot of responsibility. I learned a lot in terms of computer programming, setting up experiments, running subjects and how to analyze data. Those are skills and training that I otherwise might not have gotten until grad school."

By the time he graduated in 1996, Fenske knew that he wanted to pursue a career in academia.

"One of the driving forces for me has always been about how I can have a positive impact on others. A lot of the people who have had a major influence on my life have been teachers or instructors," he says. "If you are teaching three or four classes a year and each class has up to 100 students, you have the potential to have a positive influence on lots of people. And as an academic, when you are not preparing or giving lectures, you get to investigate important issues that you find interesting. It is a fantastic job."

Supported by NSERC scholarships, Fenske completed both a master's and PhD in psychology from the ��Ѹ��Դ��߿�Ƭ of Waterloo by 2001. After a two-year post doc at the ��Ѹ��Դ��߿�Ƭ of Wales in Bangor, Fenske moved to Boston, Mass. in 2003, where he began to integrate cognitive psychology with neuroscience, the study of the brain.

"In Boston I worked at the Martinos Center for Biomedical Imaging, where I had a dual appointment as a research fellow with Harvard Medical School and as an assistant in neuroscience at Massachusetts General Hospital (MGH). With rapid advances in neuroimaging technology, it became clear that we could learn a lot more by combining our study of human cognition with neuroscience," says Fenske. "Using MRI scanners, we were able to look at the structure of the brain and the areas of activation that related to different cognitive operations. What I now do is try to understand how it is that we do what we do. How do we pay attention to things, remember things and what elicits different emotional responses?"

Fenske spent four years at MGH and Harvard, the last two as faculty, before returning to Canada to work at the ��Ѹ��Դ��߿�Ƭ of Guelph in 2007. In spite of the years of intense research and study, he has never lost sight of his original goal of helping people.

In recent years, he has worked on bringing the knowledge he has gained about cognitive-affective neuroscience to the general public. His work on The Winner's Brain with Dr. Jeff Brown serves as an example.

"The book is all about the neuroscience of success," says Fenske. "What we do with our brain – the different ways in which we stimulate, engage and care for it – can have a significant impact on the way it works, and even alter its physical landscape. We looked at what the latest brain science says about people that excel in key areas related to success, and the various strategies the rest of us can use to fine-tune our brains and become more successful."

GET THE FACTS

· The Winner's Brain was on Amazon Canada's bestseller list, ranking 20th in the All Books category and first in both the Psychology and Success classifications. U of L neuroscience instructor, Dr. Bryan Kolb, is featured in the book.

· Fenske writes a bi-weekly column, Better Brain, for the Globe and Mail newspaper.

· He is the recipient of grants in excess of $1 million and is currently working with the Gambling Research Exchange Ontario.

· Fenske has published more than 35 articles, abstracts and theses, and has presented at more than 40 conferences and seminars.

This story first appeared in the Legend. For a full look at the January issue of the Legend, follow this link.

Fenske appreciates opportunities he was given

trevor.kenney — Thu, 20 Jan 2011 22:48:22 +0000

When he enrolled in psychology at the ��Ѹ��Դ��߿�Ƭ of Lethbridge, Dr. Mark Fenske (BSc '96, Distinction) had a goal – he wanted to help people.

The associate professor in the Department of Psychology at the ��Ѹ��Դ��߿�Ƭ of Guelph, and co-author of the Canadian best-seller, The Winner's Brain: 8 Strategies Great Minds Use to Achieve Success, initially thought about becoming a counsellor. But after the opportunity to work as a research assistant for Dr. Scott Allen opened up, Fenske found he was hooked on cognitive psychology.

Alumnus Mark Fenske is thankful for the research foundation he established while still an undergraduate.

"Lethbridge has some really good people. You get to know these people on a level that you probably wouldn't at a larger institution," says Fenske. "Working with Drs. Scott Allen, John Vokey and Don Read, who were the cognition faculty in the psychology department at the time, was a bit of an awakening for me. I was able to learn about memory, about how we interact with the world around us, what drives our behaviour, how we make decisions and how we pay attention.
"I learned there is so much more to psychology than the commonly-held view of people lying on a couch and talking about their problems."

Fenske made the most of his one-on-one opportunities with faculty.

"I was able to get a lot of face time with faculty and learn what life in a research lab is all about," he says. "It really cultivated a sense of excitement for research, and I was given a lot of responsibility.
I learned a lot in terms of computer programming, setting up experiments, running subjects and how to analyze data. Those are skills and training that I otherwise might not have gotten until grad school."

By the time he graduated in 1996, Fenske knew that he wanted to pursue a career in academia.

"One of the driving forces for me has always been about how I can have a positive impact on others. A lot of the people who have had a major influence on my life have been teachers or instructors," he says. "If you are teaching three or four classes a year and each class has up to 100 students, you have the potential to have a positive influence on lots of people. And as an academic, when you are not preparing or giving lectures, you get to investigate important issues that you find interesting. It is a fantastic job."

Supported by NSERC scholarships, Fenske completed both a master's and PhD in psychology from the ��Ѹ��Դ��߿�Ƭ of Waterloo by 2001. After a two-year post doc at the ��Ѹ��Դ��߿�Ƭ of Wales in Bangor, Fenske moved to Boston, Mass. in 2003, where he began to integrate cognitive psychology with neuroscience, the study of the brain.

"In Boston I worked at the Martinos Center for Biomedical Imaging, where I had a dual appointment as a research fellow with Harvard Medical School and as an assistant in neuroscience at Massachusetts General Hospital (MGH). With rapid advances in neuroimaging technology, it became clear that we could learn a lot more by combining our study of human cognition with neuroscience," says Fenske. "Using MRI scanners, we were able to look at the structure of the brain and the areas of activation that related to different cognitive operations. What I now do is try to understand how it is that we do what we do. How do we pay attention to things, remember things and what elicits different emotional responses?"

Fenske spent four years at MGH and Harvard, the last two as faculty, before returning to Canada to work at the ��Ѹ��Դ��߿�Ƭ of Guelph in 2007. In spite of the years of intense research and study, he has never lost sight of his original goal of helping people.

In recent years, he has worked on bringing the knowledge he has gained about cognitive-affective neuroscience to the general public. His work on The Winner's Brain with Dr. Jeff Brown serves as an example.

"The book is all about the neuroscience of success," says Fenske. "What we do with our brain – the different ways in which we stimulate, engage and care for it – can have a significant impact on the way it works, and even alter its physical landscape. We looked at what the latest brain science says about people that excel in key areas related to success, and the various strategies the rest of us can use to fine-tune our brains and become more successful."

GET THE FACTS

• The Winner's Brain was on Amazon Canada's bestseller list, ranking 20th in the All Books category and first in both the Psychology and Success classifications. U of L neuroscience instructor, Dr. Bryan Kolb, is featured in the book.

• Fenske writes a bi-weekly column, Better Brain, for the Globe and Mail newspaper.

• He is the recipient of grants in excess of $1 million and is currently working with the Gambling Research Exchange Ontario.

• Fenske has published more than 35 articles, abstracts and theses, and has presented at more than 40 conferences and seminars.

For a full look at the January issue of the Legend, follow this link.

Looking out to see in

trevor.kenney — Thu, 11 Mar 2010 16:40:59 +0000

As the lead Canadian researcher for the Canadian Space Agency's contribution to the Herschel Space Observatory, U of L scholar Dr. David Naylor (Physics and Astronomy) has played a key role in the development of the Spectral and Photometric Imaging Receiver (SPIRE). SPIRE is one of three instruments on the Herschel spacecraft that is orbiting 1.5 million km from the earth. Functioning at a chilly -270C, SPIRE observes the universe at very long wavelengths, those well beyond the limit of human vision. Radiation emitted at these wavelengths is able to travel relatively unimpeded through even the densest regions of space, which allows astronomers to view back in time to the formation of the first galaxies. This technology is similar to, but far more sophisticated than, the full body scanners now being installed at airports.

Naylor's group designs and builds exquisitely sensitive systems to convert the energy in long wavelength photons into meaningful information on the composition and physical conditions of the astronomical objects under study.

As Naylor explains, "That's what physicists do – they think of the question and then build the equipment to answer that question."

Naylor is also a co-founder of the Institute for Space Imaging Science (ISIS) and director of its Space Astronomy Division. ISIS is a collaboration between the Universities of Athabasca, Calgary and Lethbridge. Scientists from the three institutions, and their research partners worldwide, share technology and other resources to tackle leading edge questions in space imaging.

Most recently, Naylor is collaborating with Dr. Jeff Dunn, a Canada Research Chair of radiology and biophysics in the U of C's Faculty of Medicine, to explore the utility of his detection system to the medical field, initially in cancer detection. In a recent paper, a team of Taiwanese scientists have shown that THz imaging is capable of detecting breast cancer without the lengthy time requirement for histological staining of samples and visual inspection by a technician.

Naylor quickly realized that even his run of the mill detectors are 100,000 times more sensitive, which means they have the potential to identify not only the cancerous cells, but also their boundaries, substantially faster. Dunn and Naylor are working to explore if this gain can be realized.

Some people question why anyone would study astronomy. Can research into the world around us help advance us as a species? Naylor emphatically says yes.

The universe is the astronomer's laboratory, and the instrumentation Naylor has developed to look outward may just provide us a better way to see in.

"One only has to look at the impact of the laser and MRI on society, whose roots lie in basic physics research, to answer the relevance question."

New service better addresses health issues

trevor.kenney — Tue, 09 Mar 2010 21:11:31 +0000

The ��Ѹ��Դ��߿�Ƭ of Lethbridge has recently signed up with Occupational Injury Service (OIS), a new service for staff and faculty who experience a work related injury or illness.

The OIS program aligns with medical clinics that provide timely and appropriate medical care and disability management services specifically for
occupational injuries, with an emphasis on immediate (i.e., same day) communication with the employer to facilitate a safe return to work.

This service is specifically for non-emergent injuries/illnesses and provides the following benefits to staff/faculty:

• Same-day access to a physician with a background in occupational medicine and WCB-Alberta training (within 15 to 30 minutes of arrival)

• Same-day completion and submission of reports

• Identification and co-ordination of required medical services

• Earlier access to required medical and diagnostic tests, specifically MRI, CT and bone scans

• Earlier access to specialists and surgical procedures

• Completion of disability management reports that detail physical work capabilities and limitations to help determine return to work dates and tasks

• Worker and employer injury management education

• Development of a safe return-to-work plan

• Ongoing communication with the employee's family physician (OIS is a voluntary program). Staff/faculty will be given the option of attending an OIS clinic or other medical care if needed

If you experience a work related injury or illness, follow the incident/accident reporting process as usual. Report any work related injuries or illnesses to your direct supervisor, and complete the online campus incident/accident report form: http://www.uleth.ca/hum/archives/riskandsafetyservices/Services/report_form.html

If you require first aid, contact Security Services at 2345 or other appropriate responder in your area. If you require medical treatment, contact the wellness co-ordinator at 403-332-5217 and the OIS clinic of your choice will be contacted for an appointment (same day in most cases).

The OIS clinics are available Monday through Friday from 8:30 a.m. to 5 p.m.

If your injury occurs outside of these hours, you would need to access medical services through a walk-in clinic or emergency services at the hospital.
There are currently two service providers for OIS in Lethbridge:

• CBI Health – Dr. Gibb, Bigelow Fowler West; Dr. Ukrainitz, Bigelow Fowler South; Dr. Mellor

• LifeMark Health – Dr. Allen, Piedmont Clinic west; and/or Dynamic Physiotherapy

For those who work on the Calgary or Edmonton campuses, there are service providers for the program in both cities.

Calgary
• CBI Health – Midpark, Deerpark or Sunridge
• Wellpoint Health Corp
• Life Mark

Edmonton
• Medicentres Canada Inc – Westgrove, Ellerslie, Capilano, Castledowns or Millard Health

A few employees have had the opportunity to use this service already and the feedback has been very positive. Statistics show that the sooner someone is treated for an injury or illness, the sooner they are able to get back to work and participate in the other activities that make life enjoyable!

If you have any questions or would like more information, please contact Suzanne McIntosh, wellness co-ordinator at 403-332-5217.

Donors stay true with support

trevor.kenney — Thu, 05 Feb 2009 20:59:33 +0000

The ��Ѹ��Դ��߿�Ƭ of Lethbridge's 2008 fundraising results show that a healthy $7 million was raised to support more than 200 separate areas on campus – from scholarships and bursaries to research projects and equipment purchases that will make a significant difference to students and researchers.

"Despite challenging economic times that have had an impact globally, the U of L has had one of the best years ever, thanks to our generous contributors," said President Bill Cade. "Our dedicated donors made this year such a success, and we are truly grateful."

"There is no doubt that as times get tough we need individuals and private businesses to show leadership and confidence through continued investment in our community," Cade added.

"The support provided to the ��Ѹ��Դ��߿�Ƭ is a great example of this leadership. We are building something very special here at the ��Ѹ��Դ��߿�Ƭ of Lethbridge – something our community can be proud of. I think the support we received this past year shows they are already proud."

In 2008, more than 3,200 gifts were received from alumni, friends, students, and current and retired employees, with 69 per cent of those gifts destined to help students directly through student awards.

Donor generosity also enabled the ��Ѹ��Դ��߿�Ƭ to obtain more than $3 million in matching funds from the Government of Alberta through the Access to the Future Fund.

Since 2005, more than $9 million has been directed toward the ��Ѹ��Դ��߿�Ƭ of Lethbridge for scholarships, bursaries and support to the institution as a result of the province's matching program.

Generous ��Ѹ��Դ��߿�Ƭ of Lethbridge supporters featured in the 2008 Donor Report include:

- Glenn Varzari, a local Chartered Accountant, and his spouse Janice Varzari, a U of L Senator, member of the Alumni Honour Society and a counselor with Lethbridge Family Services, who supported the new Markin Hall building project for the Faculty of Management and School of Health Sciences. Their gift was matched by both the Chartered Accountants Education Foundation and the Access to the Future Fund.

- Calgary-based oil and gas entrepreneurs Darol and Evelyn Wigham, who have supported the ��Ѹ��Դ��߿�Ƭ for many years with scholarships, bursaries and books for the Faculty of Education library. Their most recent gift helped researchers at the Canadian Centre for Behavioural Neuroscience acquire specific equipment for a new Magnetic Resonance Imaging (MRI) facility.

- Internationally renowned Canadian operatic tenor -- and U of L Honorary degree recipient -- Dr. Ben Heppner, whose benefit concert in Lethbridge established an endowment for U of L music students. More than $50,000 was raised for an award that will encourage students to pursue the performing arts.

- Charlene Janes, a staff member in the U of L International Centre for Students, who has established a bursary for international students. Charlene is one of more than 280 U of L faculty, staff and retirees, who have contributed towards Supporting Our Students 2008, an annual campaign to raise money for student awards.

- Nexen Inc. and Imperial Oil, which gave to support water research initiatives. When matched through the Access to the Future Fund, their support resulted in a combined $1 million investment in water research at the U of L.

UNews - MRI

CCBN renovation creates enhanced research area

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On the forefront of an emerging science

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Fenske made the most of his U of L opportunities

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Fenske appreciates opportunities he was given

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Looking out to see in

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New service better addresses health issues

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