UNews - Catrione Lee

��Ѹ��Դ��߿�Ƭ of Lethbridge iGEM team earns gold for project that designs oral insulin delivery system

trevor.kenney — Thu, 21 Nov 2019 18:34:18 +0000

The ��Ѹ��Դ��߿�Ƭ of Lethbridge’s Collegiate iGEM team set its sights on solving a problem that affects nearly nine per cent of the world’s population, and earned a gold medal for their efforts at the recently concluded International Genetically Engineered Machines World Jamboree in Boston, Mass.

The collegiate team, accompanied by the U of L’s High School iGEM entry that achieved a silver medal standing for its project, presented Algulin, which is the development of a novel method for the manufacturing and oral delivery of insulin to diabetics.

U of L iGEM collegiate and high school team members and their advisors in Boston. Back row (L–R) Catrione Lee, David Basil, Mark Lea, Dia Koupantsis, Laura Keffer-Wilkes, Thomas Byrne, Angeliki Pantazi and Chris Isaac. Middle (kneeling L–R) Linda He, Dewuni De Silva, Michelle Wu and Luke Saville. Front – Julien Todd.

“We wanted to do something different and meaningful, something that will have a positive effect on the people around us,” says Dia Koupantsis, a third-year biological sciences student. “So, we developed the project Algulin, an oral insulin manufactured in microalgae, in an attempt to democratize the manufacturing of insulin so that it can be widely available for individuals who need it.”

Diabetes is a massive global issue that requires lifelong management for those affected, imposing an enormous economic health burden that amounts to a $673 billion global expenditure annually. Currently, the most common method of relieving diabetes symptoms is through painful, expensive insulin injections. Some patients must self-administer the drug up to six times per day.

After interviewing diabetic patients, doctors and pharmacists, the iGEM team went about trying to find a way to deliver insulin to patients orally. The challenge, which has thwarted previous attempts, is to find a way to get the insulin through the stomach acid and into the small intestine for absorption without becoming seriously degraded. Their solution – microalgae.

Algulin is an oral insulin produced in microalgae. After testing three different microalgae, the group determined Cyanidioschyzon merolae, with its innate acid resistant membrane, could survive the stomach environment. Additionally, with a carbohydrate-based cell wall, C. merolae would degrade in the small intestine and allow for the therapeutic insulin to be absorbed through to its intended target — the portal vein.

“It was a challenging project because it involved working with an organism we’d never used before,” says Luke Saville, a fourth-year biochemistry student. “This promoted challenges in learning how to grow the organism and how to genetically engineer it to produce our insulin.”

U of L chemistry & biochemistry instructor Dr. Angeliki Pantazi is one of the team’s faculty mentors and lauds the team for the work they put in and the further potential of their project.

“The gold medal is exciting but it’s a little bit less about what we came back with and more about how we are training the next generation of scientists and leaders through these programs,” she says. “It’s a very student-driven program and I was impressed with why they wanted to pursue this project. They were concerned about people not being able to afford insulin and inspired by the first two Canadian scientists who isolated purified insulin and how they didn’t patent it for themselves but instead offered it to humankind for free.”

Now that the iGEM season is over, it’s up to the group to find possible investors to continue their work and eventually try and get a product to market. The next stage would be performing animal studies to see how the insulin is being transferred into the bloodstream and how it functions.

“I think it has great commercial potential,” says Saville. “By moving away from injectables and purification free insulin growth, we can dramatically lower the cost of diabetes management while providing a more comfortable way to administer medicine.”

Other members of the collegiate team included: Catrione Lee, Kalob Barr, Jesse Holbein, Allyson Lawrie-White, Landon McCabe, Joshua Omotosho, Kera Whitten and Dong Ju Kim. Graduate student advisors included Sydnee Calhoun, Aubrey Demchuk, Chris Isaac and Kristi Turton while Dr. Trushar Patel (chemistry & biochemistry) was the secondary investigator.

High school team earns silver

All four local high schools contributed to the team that presented CADAR (CRISPR assisted detection and removal) at the World Jamboree, a project designed to create a rapid diagnostic tool for identifying bacterial pathogens.

“Our team decided to choose CADAR because we saw the increasing prevalence of antibiotic resistance in pathogenic bacteria,” says Mark Lea, a Chinook High School graduate who is now in his first year at the U of L. “We found, through initial research, that there is a lot of over-prescription of antibiotics that further increases the amount of bacterial resistance. We thought finding an alternative and more novel approach to traditional antibiotic methods of identifying and then eliminating those pathogens would be an interesting project.”

Dr. Laura Keffer-Wilkes, the manager of Synbridge and high school team advisor, says the project was very ambitious for the high school group and she was pleased with the work they put in to try and develop a product that could be used in health care and patient care settings, in processing plants and even ambulances as a means to validate cleaning practices.

“It’s really student-driven, so they go after whatever motivates them, whatever passions they have,” she says. “As a high school instructor, I don’t want to stifle their creativity, and they used some very advanced technology in their work.”

The high school team consisted of: Alice Zhang, Andy Sun, Aroma Pageni, David Basil, Dewuni De Silva, Elisha Wong, Julien Todd, Karen He, Linda He, Katie Vienneau, Mark Lea, Michelle Wu, Mina Akbary, Natasha Woitte, Rachel Avileli, Rebecca Avileli, Shada Aborawi and Thomas Byrne.

Opening of Science Commons ushers in new era for ��Ѹ��Դ��߿�Ƭ of Lethbridge

trevor.kenney — Fri, 13 Sep 2019 15:30:42 +0000

A new era in scientific research and education has dawned with today’s official opening of the ��Ѹ��Դ��߿�Ƭ of Lethbridge’s $280-million Science Commons.

The spectacular facility, which brings together the departments of Chemistry & Biochemistry, Biological Sciences, Neuroscience, Physics & Astronomy and Psychology, is designed to foster transdisciplinary research by providing exceptional opportunities for collaboration and discovery.

At 38,500 sq. metres, it is the largest development on the U of L campus since the original construction of ��Ѹ��Դ��߿�Ƭ Hall began in 1969.

“The history of the ��Ѹ��Դ��߿�Ƭ of Lethbridge is steeped in a tradition of community visionaries coming together to make the improbable possible, just as they did in establishing the ��Ѹ��Դ��߿�Ƭ over 50 years ago,” says Dr. Mike Mahon, U of L president and vice-chancellor. “It took a great community effort to bring the dream of Science Commons together as well. From our incredible faculty and staff, to alumni and donors, our Board of Directors and Senate and all our partners throughout southern Alberta, Science Commons will stand as a testament to visionary thought and perseverance and represent the very best our ��Ѹ��Դ��߿�Ƭ has to offer.”

Alberta Premier Jason Kenney says the addition of Science Commons at the U of L is a boon for the province.

“On behalf of the Government of Alberta, I congratulate the ��Ѹ��Դ��߿�Ƭ of Lethbridge on the opening of Science Commons,” says Kenney “This facility will help thousands of students to learn, innovate and collaborate for decades to come. This project will receive $260 million from Alberta taxpayers, underscoring our province’s commitment to scientific progress, which is critical to our long-term prosperity.”

Demetrios Nicolaides, Alberta’s Minister of Advanced Education, adds that the province’s investment will bolster intellectual capital and strengthen the economy.

“The ��Ѹ��Դ��߿�Ƭ of Lethbridge has an outstanding reputation for discovery research. The addition of this state-of-the-art facility will further attract international students and inspire more innovation, creativity and growth,” says Nicolaides. “A modern university research centre brings top talent and business to Alberta which builds the workforce and supports a stronger economy.”

Setting the stage for the next 50 years of scientific discovery and education at the U of L, Science Commons is a facility where science transcends disciplines. Large, flexible lab spaces designed with a shared-space ideology encourage collisions among researchers with diverse backgrounds and approaches. Researchers at all stages of their careers, from postdocs to doctoral, masters and undergraduate students and from kindergarten to Grade 12 will come together, sparking conversations and igniting discovery.

Setting the stage for the next 50 years of scientific discovery and education at the U of L, Science Commons is a facility where science transcends disciplines.

“From the outset, the vision of our faculty members was to stay true to our liberal education roots. The key to the success of this facility is to foster a culture of discovery and innovation that is outward-facing, responsive to societal needs and inspires the next generation,” says Dr. Matthew Letts, interim dean for the Faculty of Arts & Science. “Science Commons will build upon our collaborative approach to research and our experiential approach to learning.”

The facility also creates greater opportunity for the ��Ѹ��Դ��߿�Ƭ to build on its relationships with southern Alberta industry partners.

“The U of L has long been an economic driver in our community and Science Commons will expand our ability to foster partnerships as we translate knowledge from the lab to industry,” adds Mahon.

Dr. Ute Kothe, a researcher in the Department of Chemistry & Biochemistry, says the world-class research already being conducted at the U of L will be further enhanced by the amenities within Science Commons.

“This building will draw scientists to Lethbridge, and that will really ensure we are bringing the best minds to Lethbridge to conduct world-class research here,” says Kothe. “They will work in state-of-the-art facilities and they will learn to work collaboratively because this is really the philosophy of the U of L — to bring people together and cross disciplinary boundaries and generate the best ideas.”

With glass the defining design feature of Science Commons, it embodies the concept of science on display, serving as an open invitation to the public to see the world’s brightest minds as they work to solve today’s greatest challenges. Further, the facility offers dedicated spaces that will double the ��Ѹ��Դ��߿�Ƭ’s capacity for science outreach activities — a true science centre for southern Alberta.

“What makes Science Commons so extraordinary is by the manner in which the architecture and the facility have been structured to foster research, teaching, collaborative space, public space, all in a domain that actually brings together multidisciplinary researchers and the public at large,” says Dr. Fred Wrona, chief scientist, Alberta Environment and Parks, Government of Alberta.

Students are taking notice. New Fall 2019 registrants to Bachelor of Science (BSc) programs offered by the Faculty of Arts & Science are up over 23 per cent from last year, while total BSc registrants are up nearly 10 per cent.

“The open concept allows for a lot of collaboration between different labs, so I’m excited to learn with new tools and new techniques that I might not have had access to before,” says Catrione Lee, a fourth-year biochemistry student.

Already one of the country’s leading research universities, Science Commons positions the U of L at the forefront of science research and education, inspiring the next generation of research scientists and setting the stage for an unprecedented era of discovery.

Dr. Hans-Joachim Wieden, Alberta Innovates Strategic Chair in RNA Bioengineering, Tier I Board of Governors Research Chair in Biomolecular Design and Function and the founding director of the Alberta RNA Research and Training Institute (ARRTI), is succinct in his appraisal of Science Commons.

“I’m convinced that this facility is the best facility for research and science education in Canada.”

UPDATE

Just prior to the offical opening ceremony, Science Commons was blessed and elder Francis First Charger bestowed the Blackfoot name Isttaniokaksini on the facility. Its meaning refers to deep knowledge and awareness rising out of the unknown into the known.

U of L iGEM teams tackling relevant issues, awarded gold and silver at Giant Jamboree

trevor.kenney — Tue, 06 Nov 2018 21:13:23 +0000

The ��Ѹ��Դ��߿�Ƭ of Lethbridge’s iGEM students have proven once again they are among the best and brightest scientists in the synthetic biology field.

The U of L's collegiate iGEM representatives who presented in Boston.

From over 300 teams, representing countries from all over the world, the U of L’s collegiate team secured a gold medal and the high school entry a silver at the 2018 International Genetically Engineered Machine (iGEM) competition in Boston, MA.

The collegiate team’s project VINCEnT focused on developing tools for other synthetic biology researchers. Targeting specific tissues, cell types, or cellular organelles is important for the correct treatment of many diseases. The U of L team created software that would help others overcome these problems. The team members also demonstrated how they can successfully encapsulate cargo within P22 “nanocompartments” that can target Zebra and Quagga mussels with species-specific toxins. One of the largest problems facing Alberta waterways, Zebra and Quagga mussels are considered aquatic invasive species and a threat to the Alberta economy, specifically agriculture, tourism and recreation as they destroy natural lake ecosystems and fisheries. Work on this application will continue in the future.

The U of L's high school team impressed with a silver medal standing.

The U of L team of Sydnee Calhoun, Kristi Turton, Catrione Lee and Luke Saville presented at the jamboree and were supported by team members Keith Aiken, Maya Degrood, Simmone D’Souza, Travis Haight, DJ Kim, Jessica Semmelrock, Reanna Takeyasu and David Tobin. Aubrey Demchuk, Graeme Glaister, Zak Stinson and secondary investigator Dr. Trushar Patel served as advisors.

The Lethbridge high school team is comprised of students from Winston Churchill High School, Lethbridge Collegiate Institute, Chinook High School and Catholic Central High School. Members Mark Lea, Michelle Wu and Andy Sun travelled to Boston to represent the team. Their project, Cu Later, described a method for the capture and removal of metals from tailings ponds and effluent water using an engineered bacteriophage system and received a silver medal and nomination for best model.

Dewuni De Silva, Aidan Sander, Nicolas Parra, Aroma Pageni, Rebecca Avileli, Tyler Black, Logan Black, Alice Zhang, Karen He, Mina Akbary-Zheng, Emily Huynh and Nimaya De Silva supported their teammates’ efforts from Lethbridge. Recruitment for the 2019 Lethbridge high school iGEM team will begin in January.

Representatives from the ��Ѹ��Դ��߿�Ƭ of Lethbridge were also involved in core activities for the iGEM Giant Jamboree. Dr. Hans-Joachim Wieden, also a primary investigator for the U of L collegiate team, was one of the competition judges, and Chris Isaac, U of L biochemistry graduate student, participated in the iGEM Safety Committee.

The projects and accomplishments of the university and high school teams are available on their wiki websites. Also, follow the high school team’s progress on social media: @LethHS_iGEM and @lethbridgehsiGEM. The U of L team can be followed here: @LethbridgeiGEM.

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��Ѹ�����Դ���߿�Ƭ of Lethbridge iGEM team earns gold for project that designs oral insulin delivery system

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